The effect of hypohydration on endothelial function in young healthy adults.
Eur J Nutr
; 56(3): 1211-1217, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-26864199
ABSTRACT
PURPOSE:
Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function.METHODS:
Ten young, healthy males participated in this crossover study (age 24.3 ± 2.3 year; weight 80.8 ± 5.3 kg; BMI 24.3 ± 0.4 kg m-2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of -2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded.RESULTS:
Hypohydration by -1.9 ± 0.1 % of body mass resulted in decreased plasma volume by -3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg-1 (P < 0.001). FMD as a response to hypohydration decreased by -26.8 ± 3.9 % (P < 0.05).CONCLUSION:
The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Deshidratación
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2017
Tipo del documento:
Article
País de afiliación:
Grecia