The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies.
Eur Neurol
; 75(1-2): 82-8, 2016.
Article
en En
| MEDLINE
| ID: mdl-26867030
ABSTRACT
BACKGROUND/AIMS:
We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs).METHODS:
Babs (ELISA) and Nabs (antiviral cytopathic effect assay) titers were evaluated before, immediately after and at 1 month following ivMP in 60 MS patients.RESULTS:
ivMP reduces Nabs and Babs titers for at least 1 month. Baseline titers determine Nabs and Babs seronegativity at the end of ivMP. Clinical response to ivMP tends to be better in Nabs(+) patients.CONCLUSION:
Sampling for Nabs/Babs should be avoided during or shortly after ivMP to avoid transient positive or negative results that may obscure the decision to switch treatment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Metilprednisolona
/
Interferón beta
/
Fármacos Neuroprotectores
/
Anticuerpos Neutralizantes
/
Esclerosis Múltiple
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Eur Neurol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Grecia