10-Second heart rate variability and cognitive function in old age.
Neurology
; 86(12): 1120-7, 2016 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-26888988
ABSTRACT
OBJECTIVE:
To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease.METHODS:
We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domains were assessed at baseline and repeated during a mean follow-up period of 3.2 years.RESULTS:
Lower HRV at baseline was associated with worse performance in reaction time (mean difference between low third vs high third of HRV = 1.96 seconds, 95% confidence interval [CI] 0.20 to 3.71) and processing speed (-0.57 digits coded, 95% CI -1.09 to -0.05). During follow-up, participants with lower HRV had a steeper decline in processing speed (mean annual change between low third vs high third of HRV = -0.16 digits coded, 95% CI -0.28 to -0.04). There was no difference in annual changes of reaction time or immediate and delayed memory among HRV thirds during follow-up. All these associations remained unchanged after adjustment for medications, cardiovascular risk factors, and comorbidities.CONCLUSIONS:
Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Cognición
/
Electrocardiografía
/
Frecuencia Cardíaca
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido