Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.

Ingram, Melissa; Wozniak, Emily A L; Duvick, Lisa; Yang, Rendong; Bergmann, Paul; Carson, Robert; O'Callaghan, Brennon; Zoghbi, Huda Y; Henzler, Christine; Orr, Harry T

Ingram, Melissa; Wozniak, Emily A L; Duvick, Lisa; Yang, Rendong; Bergmann, Paul; Carson, Robert; O'Callaghan, Brennon; Zoghbi, Huda Y; Henzler, Christine; Orr, Harry T.

Afiliación

Ingram M; Institute for Translational Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Wozniak EAL; Department of Genetics, Cell Biology, and Development, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Duvick L; Institute for Translational Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Yang R; Department of Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Bergmann P; Institute for Translational Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Carson R; Department of Laboratory Medicine and Pathology, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
O'Callaghan B; RISS Bioinformatics, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Zoghbi HY; Foresight Logic, Inc., Shoreview, MN 55126.
Henzler C; Institute for Translational Neuroscience, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.
Orr HT; Department of Laboratory Medicine and Pathology, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455.

Neuron ; 89(6): 1194-1207, 2016 Mar 16.

Article en En | MEDLINE | ID: mdl-26948890

Asunto(s)

Ataxina-1/genética; Cerebelo/metabolismo; Cerebelo/patología; Ataxias Espinocerebelosas/patología; Transcriptoma/genética; Animales; Ataxina-1/metabolismo; Quimiocinas CC/deficiencia; Quimiocinas CC/genética; Colecistoquinina/deficiencia; Colecistoquinina/genética; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Redes Reguladoras de Genes; Factores de Intercambio de Guanina Nucleótido/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos; Proteínas del Tejido Nervioso/metabolismo; Neuropéptidos/metabolismo; Proteínas Nucleares/metabolismo; Péptidos/genética; Péptidos/metabolismo; Células de Purkinje/metabolismo; Receptor de Colecistoquinina B/deficiencia; Receptor de Colecistoquinina B/genética; Regulación hacia Arriba/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cerebelo / Ataxias Espinocerebelosas / Transcriptoma / Ataxina-1 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article

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