Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network.
Curr Top Dev Biol
; 117: 497-521, 2016.
Article
en En
| MEDLINE
| ID: mdl-26969997
ABSTRACT
The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start at gastrulation, are accompanied by the spatiotemporal activity of transcription factors and signaling pathways that drives lineage specification, germ layer formation, and cell/tissue movement. The morphogenesis, regionalization, and patterning of the brain and craniofacial structures rely on the function of LIM-domain, homeodomain, and basic helix-loop-helix transcription factors. These factors constitute the central nodes of a gene regulatory network (GRN) which encompasses and intersects with signaling pathways involved with head formation. It is predicted that the functional output of this "head GRN" impacts on cellular function and cell-cell interactions that are essential for lineage differentiation and tissue modeling, which are key processes underpinning the formation of the head.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Regulación del Desarrollo de la Expresión Génica
/
Linaje de la Célula
/
Desarrollo Embrionario
/
Embrión de Mamíferos
/
Redes Reguladoras de Genes
/
Cabeza
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Curr Top Dev Biol
Año:
2016
Tipo del documento:
Article