Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules.

Westerlund, Kristina; Honarvar, Hadis; Norrström, Emily; Strand, Joanna; Mitran, Bogdan; Orlova, Anna; Eriksson Karlström, Amelie; Tolmachev, Vladimir

Westerlund, Kristina; Honarvar, Hadis; Norrström, Emily; Strand, Joanna; Mitran, Bogdan; Orlova, Anna; Eriksson Karlström, Amelie; Tolmachev, Vladimir.

Afiliación

Westerlund K; Division of Protein Technology, School of Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center , 106 91 Stockholm, Sweden.
Honarvar H; Institute for Immunology, Genetics and Pathology, Uppsala University , 751 05 Uppsala, Sweden.
Norrström E; Division of Protein Technology, School of Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center , 106 91 Stockholm, Sweden.
Strand J; Institute for Immunology, Genetics and Pathology, Uppsala University , 751 05 Uppsala, Sweden.
Mitran B; Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University , 751 05 Uppsala, Sweden.
Orlova A; Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University , 751 05 Uppsala, Sweden.
Eriksson Karlström A; Division of Protein Technology, School of Biotechnology, KTH Royal Institute of Technology, AlbaNova University Center , 106 91 Stockholm, Sweden.
Tolmachev V; Institute for Immunology, Genetics and Pathology, Uppsala University , 751 05 Uppsala, Sweden.

Mol Pharm ; 13(5): 1668-78, 2016 05 02.

Article en En | MEDLINE | ID: mdl-27010700

Asunto(s)

Quelantes/química; Proteínas/química; Proteínas/metabolismo; Radiofármacos/química; Amidas/química; Animales; Línea Celular Tumoral; Femenino; Radioisótopos de Galio/química; Humanos; Radioisótopos de Indio/química; Marcaje Isotópico/métodos; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Imagen Molecular/métodos; Radioisótopos/química; Receptor ErbB-2/metabolismo; Distribución Tisular

Palabras clave

Affibody molecule; DOTAGA; HER2; molecular imaging; radiolabeling

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Quelantes / Radiofármacos Límite: Animals / Female / Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Suecia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google