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Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.
Homberg, Judith R; Kyzar, Evan J; Nguyen, Michael; Norton, William H; Pittman, Julian; Poudel, Manoj K; Gaikwad, Siddharth; Nakamura, Shun; Koshiba, Mamiko; Yamanouchi, Hideo; Scattoni, Maria Luisa; Ullman, Jeremy F P; Diamond, David M; Kaluyeva, Aleksandra A; Parker, Matthew O; Klimenko, Victor M; Apryatin, Sergey A; Brown, Richard E; Song, Cai; Gainetdinov, Raul R; Gottesman, Irving I; Kalueff, Allan V.
Afiliación
  • Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
  • Kyzar EJ; Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Nguyen M; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
  • Norton WH; Department of Biology, University of Leicester, Leicester, UK.
  • Pittman J; Department of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
  • Poudel MK; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Gaikwad S; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Nakamura S; Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Koshiba M; Departments of Pediatrics and Biochemistry, Saitama Medical University, Saitama, Japan.
  • Yamanouchi H; Departments of Pediatrics and Biochemistry, Saitama Medical University, Saitama, Japan.
  • Scattoni ML; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
  • Ullman JF; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
  • Diamond DM; Department of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
  • Kaluyeva AA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
  • Parker MO; School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
  • Klimenko VM; Pavlov Physiology Department, Institute of Experimental Medicine IEM RAS, St. Petersburg, Russia.
  • Apryatin SA; Research Institute of Nutrition RAS, Moscow, Russia.
  • Brown RE; Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Song C; Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Neuroscience Institute, China Medical University
  • Gainetdinov RR; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
  • Gottesman II; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
  • Kalueff AV; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institutes of Chemical Technology and Natural Sciences,
Neurosci Biobehav Rev ; 65: 292-312, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27048961
ABSTRACT
Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos del Neurodesarrollo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurosci Biobehav Rev Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos del Neurodesarrollo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurosci Biobehav Rev Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos