Synaptic AMPA receptor composition in development, plasticity and disease.
Nat Rev Neurosci
; 17(6): 337-50, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-27080385
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1-4, that mediate most fast excitatory neurotransmission. The component subunits determine the functional properties of AMPARs, and the prevailing view is that the subunit composition also determines AMPAR trafficking, which is dynamically regulated during development, synaptic plasticity and in response to neuronal stress in disease. Recently, the subunit dependence of AMPAR trafficking has been questioned, leading to a reappraisal of this field. In this Review, we discuss what is known, uncertain, conjectured and unknown about the roles of the individual subunits, and how they affect AMPAR assembly, trafficking and function under both normal and pathological conditions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sinapsis
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Receptores AMPA
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Neurogénesis
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Enfermedades del Sistema Nervioso
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Plasticidad Neuronal
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Neuronas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article