[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum.
J Nat Prod
; 79(5): 1454-8, 2016 05 27.
Article
en En
| MEDLINE
| ID: mdl-27082849
ABSTRACT
A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Apoptosis
/
Hojas de la Planta
/
Zanthoxylum
Límite:
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Nat Prod
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil