Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube.
Dev Cell
; 37(2): 127-35, 2016 Apr 18.
Article
en En
| MEDLINE
| ID: mdl-27093082
ABSTRACT
Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly understood. We have examined this phenomenon in the context of the patterning of the ventral neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two species that differ in size during the time of neural tube patterning. We find that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3. This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación del Desarrollo de la Expresión Génica
/
Tipificación del Cuerpo
/
Proteínas Hedgehog
/
Tubo Neural
/
Proteínas del Tejido Nervioso
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Dev Cell
Asunto de la revista:
EMBRIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos