Steroid constituents from the soft coral Sinularia microspiculata.
J Asian Nat Prod Res
; 18(10): 938-44, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27151101
ABSTRACT
A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (1) and 16α-hydroxysarcosterol (2). Their structures were determined on the basis of spectroscopic data ((1)H and (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, 3 showed weak cytotoxic effects against HL-60 (IC50 = 89.02 ± 9.93 µM) cell line, whereas 5 was weakly active against HL-60 (IC50 = 82.80 ± 13.65 µM) and SK-Mel2 (IC50 = 72.32 ± 1.30 µM) cell lines.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esteroides
/
Colesterol
/
Antozoos
/
Deshidrocolesteroles
/
Antineoplásicos
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Vietnam