Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Glia
; 64(10): 1788-94, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27246804
ABSTRACT
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;641788-1794.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Microglía
/
Minociclina
/
Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Glia
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article