Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E-deficient mice and cells.

Ryu, Hye-Myung; Kim, You-Jin; Oh, Eun-Joo; Oh, Se-Hyun; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Park, Sun-Hee; Kim, Yong-Lim

Ryu, Hye-Myung; Kim, You-Jin; Oh, Eun-Joo; Oh, Se-Hyun; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Park, Sun-Hee; Kim, Yong-Lim.

Afiliación

Ryu HM; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim YJ; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Oh EJ; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Oh SH; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Korea.
Choi JY; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Cho JH; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim CD; Cell and Matrix Research Institute, Kyungpook National University, Daegu, Korea.
Park SH; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kim YL; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Korea.

J Cell Mol Med ; 20(11): 2160-2172, 2016 11.

Article en En | MEDLINE | ID: mdl-27396856

Asunto(s)

Apolipoproteínas E/deficiencia; Aterosclerosis/patología; Colesterol/metabolismo; Hipoxantina/farmacología; Acetilcisteína/farmacología; Alopurinol/farmacología; Animales; Apolipoproteínas E/metabolismo; Aterosclerosis/sangre; Colesterol/sangre; Regulación hacia Abajo/efectos de los fármacos; Regulación hacia Abajo/genética; Células Hep G2; Humanos; Peróxido de Hidrógeno/toxicidad; Hipercolesterolemia/patología; Lipogénesis/efectos de los fármacos; Lipogénesis/genética; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Modelos Biológicos; Placa Aterosclerótica/sangre; Placa Aterosclerótica/metabolismo; Placa Aterosclerótica/patología; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

APOE; ROS; atherosclerosis; cholesterol; hypoxanthine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Colesterol / Hipoxantina / Aterosclerosis Límite: Animals / Humans / Male Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article

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