Inhibition of the oxidative stress-induced miR-23a protects the human retinal pigment epithelium (RPE) cells from apoptosis through the upregulation of glutaminase and glutamine uptake.

Li, Dan-Dan; Zhong, Bin-Wu; Zhang, Hai-Xia; Zhou, Hong-Yan; Luo, Jie; Liu, Yang; Xu, Gui-Chun; Luan, Chun-Sheng; Fang, Jun

Li, Dan-Dan; Zhong, Bin-Wu; Zhang, Hai-Xia; Zhou, Hong-Yan; Luo, Jie; Liu, Yang; Xu, Gui-Chun; Luan, Chun-Sheng; Fang, Jun.

Afiliación

Li DD; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China. li_dandan_2015@163.com.
Zhong BW; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Zhang HX; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Zhou HY; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Luo J; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Liu Y; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Xu GC; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Luan CS; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.
Fang J; Department of Ophthalmology, Daqing Oilfield General Hospital, No. 9 Zhongkang Street, Saertu District, Daqing, 163000, Heilongjiang, China.

Mol Biol Rep ; 43(10): 1079-87, 2016 Oct.

Article en En | MEDLINE | ID: mdl-27411920

Asunto(s)

Glutaminasa/metabolismo; Glutamina/metabolismo; MicroARNs/genética; Epitelio Pigmentado de la Retina/efectos de los fármacos; Regulación hacia Arriba; Apoptosis; Línea Celular; Supervivencia Celular/efectos de los fármacos; Regulación de la Expresión Génica/efectos de los fármacos; Glutaminasa/genética; Humanos; Peróxido de Hidrógeno/toxicidad; Estrés Oxidativo; Epitelio Pigmentado de la Retina/citología; Epitelio Pigmentado de la Retina/metabolismo

Palabras clave

Apoptosis; Glutaminase; Glutamine; The human retinal pigment epithelium cells; The oxidative stress-induced miR-23a

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación hacia Arriba / MicroARNs / Epitelio Pigmentado de la Retina / Glutaminasa / Glutamina Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2016 Tipo del documento: Article País de afiliación: China

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