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Leukocyte DNA damage after reduced and conventional absorbed radiation doses using 3rd generation dual-source CT technology.
Popp, Henning D; Meyer, Mathias; Brendel, Susanne; Prinzhorn, Wiltrud; Naumann, Nicole; Weiss, Christel; Seifarth, Wolfgang; Schoenberg, Stefan O; Hofmann, Wolf-K; Henzler, Thomas; Fabarius, Alice.
Afiliación
  • Popp HD; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Meyer M; Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Brendel S; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Prinzhorn W; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Naumann N; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Weiss C; Department of Statistical Analysis, Medical Faculty Mannheim of the University of Heidelberg, Ludolf-Krehl-Strasse 13-17, 68167 Mannheim, Germany.
  • Seifarth W; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Schoenberg SO; Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Hofmann WK; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Henzler T; Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Fabarius A; Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Eur J Radiol Open ; 3: 134-7, 2016.
Article en En | MEDLINE | ID: mdl-27437433
ABSTRACT

PURPOSE:

Computed tomography (CT) scans are an important source of ionizing irradiation (IR) in medicine that can induce a variety of DNA damage in human tissues. With technological improvements CT scans at reduced absorbed doses became feasible presumably lowering genotoxic side effects. MATERIALS AND

METHODS:

For measuring DNA damage we performed γH2AX foci microscopy in peripheral blood mononuclear cells (PBMC) after exposure to reduced and conventional absorbed radiation doses using 3rd generation dual-source CT (DSCT) technology.

RESULTS:

CT scans performed at reduced absorbed doses of 3 mGy induced significant lower levels (p < 0.0001) of DNA damage (0.05 focus per cell ± 0.01 [mean ± standard error of mean]) at 5 min after IR compared to conventional absorbed doses of 15 mGy (0.30 focus per cell ± 0.03). With ongoing DNA repair background γH2AX foci levels (0.05 focus per cell) were approached at 24 h after CT with both protocols.

CONCLUSION:

Our results provide evidence that reduced absorbed doses mediated by adjusted tube current in 3rd generation DSCT induce lower levels of DNA damage in PBMC compared to conventional absorbed doses suggesting a lower genotoxic risk for state-of-the-art tube current reduced CT protocols.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Eur J Radiol Open Año: 2016 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Eur J Radiol Open Año: 2016 Tipo del documento: Article País de afiliación: Alemania