Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.

Grunert, Marcel; Dorn, Cornelia; Cui, Huanhuan; Dunkel, Ilona; Schulz, Kerstin; Schoenhals, Sophia; Sun, Wei; Berger, Felix; Chen, Wei; Sperling, Silke R

Grunert, Marcel; Dorn, Cornelia; Cui, Huanhuan; Dunkel, Ilona; Schulz, Kerstin; Schoenhals, Sophia; Sun, Wei; Berger, Felix; Chen, Wei; Sperling, Silke R.

Afiliación

Grunert M; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany Group of Cardiovascular Genetics, Department of Vertebrate Ge
Dorn C; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany Group of Cardiovascular Genetics, Department of Vertebrate Ge
Cui H; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany Department of Biology, Chemistry and Pharmacy, Freie Universi
Dunkel I; Group of Cardiovascular Genetics, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany.
Schulz K; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany.
Schoenhals S; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany Department of Biology, Chemistry and Pharmacy, Freie Universi
Sun W; Laboratory for Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Berger F; Department of Pediatric Cardiology, German Heart Institute Berlin and Department of Pediatric Cardiology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Chen W; Laboratory for Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Sperling SR; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Lindenberger Weg 80, 13125 Berlin, Germany Group of Cardiovascular Genetics, Department of Vertebrate Ge

Cardiovasc Res ; 112(1): 464-77, 2016 10.

Article en En | MEDLINE | ID: mdl-27496870

Asunto(s)

Proteínas Portadoras/genética; Metilación de ADN; Epigénesis Genética; Perfilación de la Expresión Génica/métodos; Defectos del Tabique Interventricular/genética; Proteínas Mitocondriales/genética; Tetralogía de Fallot/genética; Adaptación Fisiológica; Adulto; Estudios de Casos y Controles; Preescolar; Islas de CpG; Redes Reguladoras de Genes; Estudios de Asociación Genética; Marcadores Genéticos; Predisposición Genética a la Enfermedad; Defectos del Tabique Interventricular/fisiopatología; Hemodinámica; Humanos; Lactante; Persona de Mediana Edad; Chaperonas Moleculares; Fenotipo; Análisis de Componente Principal; Regiones Promotoras Genéticas; Empalme del ARN; Reproducibilidad de los Resultados; Tetralogía de Fallot/fisiopatología; Adulto Joven

Palabras clave

Congenital heart disease; DNA methylation; Gene expression; Tetralogy of Fallot; Ventricular septal defect

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tetralogía de Fallot / Proteínas Portadoras / Metilación de ADN / Perfilación de la Expresión Génica / Proteínas Mitocondriales / Epigénesis Genética / Defectos del Tabique Interventricular Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Child, preschool / Humans / Infant / Middle aged Idioma: En Revista: Cardiovasc Res Año: 2016 Tipo del documento: Article

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