[Expression of PTEN in Myocardial Tissue in Coronary Heart Disease].
Fa Yi Xue Za Zhi
; 32(2): 94-6, 104, 2016 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-27501678
ABSTRACT
OBJECTIVE:
To observe the expression of phosphatase and tensin homology deleted on chromosome ten (PTEN) in myocardial tissue in patients with coronary heart disease, and explore the relevance between the expression of PTEN and the occurrence and development of coronary heart disease.METHODS:
A total of 16 death cases with pathological diagnosis of coronary heart disease were collected as experimental group, and 19 cases without myocardial lesions were selected as control group. The expression of PTEN protein and its mRNA were detected by immunohistochemistry and real-time fluorescence quantitative PCR respectively. The correlation between the expression of PTEN and the pathogenesis of coronary heart disease was analyzed.RESULTS:
The expression of PTEN protein in myocardium in cases with coronary heart disease was significantly lower compared with the control group (P < 0.05). There was no statistical difference of the expression of PTEN mRNA between experimental and control group (P > 0.05).CONCLUSION:
PTEN may be involved in the occurrence and development of coronary heart disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Fosfohidrolasa PTEN
/
Miocardio
Límite:
Humans
Idioma:
Zh
Revista:
Fa Yi Xue Za Zhi
Asunto de la revista:
JURISPRUDENCIA
Año:
2016
Tipo del documento:
Article