BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia.

Chen, Li-Tzong; Chen, Chiung-Tong; Jiaang, Weir-Torn; Chen, Tsai-Yun; Butterfield, Joseph H; Shih, Neng-Yao; Hsu, John Tsu-An; Lin, Hui-You; Lin, Sheng-Fung; Tsai, Hui-Jen

Chen, Li-Tzong; Chen, Chiung-Tong; Jiaang, Weir-Torn; Chen, Tsai-Yun; Butterfield, Joseph H; Shih, Neng-Yao; Hsu, John Tsu-An; Lin, Hui-You; Lin, Sheng-Fung; Tsai, Hui-Jen.

Afiliación

Chen LT; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, Kaohsiung Medical U
Chen CT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
Jiaang WT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
Chen TY; Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Butterfield JH; Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota.
Shih NY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
Hsu JT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
Lin HY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
Lin SF; Division of Hematology/Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tsai HJ; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, Kaohsiung Medical U

Mol Cancer Ther ; 15(10): 2323-2333, 2016 10.

Article en En | MEDLINE | ID: mdl-27512117

Asunto(s)

Leucemia Mieloide Aguda/genética; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas c-kit/antagonistas & inhibidores; Proteínas Proto-Oncogénicas c-kit/genética; Animales; Apoptosis/efectos de los fármacos; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Ciclo Celular/efectos de los fármacos; Ciclo Celular/genética; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Modelos Animales de Enfermedad; Humanos; Leucemia Mieloide Aguda/tratamiento farmacológico; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/patología; Masculino; Ratones; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Mutación; Fosforilación; Inhibidores de Proteínas Quinasas/administración & dosificación; Proteínas Proto-Oncogénicas c-kit/metabolismo; Transducción de Señal/efectos de los fármacos; Activación Transcripcional; Translocación Genética; Carga Tumoral/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Proteínas Proto-Oncogénicas c-kit / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2016 Tipo del documento: Article

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