Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential.

Juhl, Cathleen; Els-Heindl, Sylvia; Schönauer, Ria; Redlich, Gorden; Haaf, Erik; Wunder, Frank; Riedl, Bernd; Burkhardt, Nils; Beck-Sickinger, Annette G; Bierer, Donald

Juhl, Cathleen; Els-Heindl, Sylvia; Schönauer, Ria; Redlich, Gorden; Haaf, Erik; Wunder, Frank; Riedl, Bernd; Burkhardt, Nils; Beck-Sickinger, Annette G; Bierer, Donald.

Afiliación

Juhl C; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Els-Heindl S; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
Schönauer R; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
Redlich G; Global External Innovation & Alliances, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Haaf E; Department of Pharmacokinetics and Metabolism, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Wunder F; Lead Discovery Wuppertal, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Riedl B; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Burkhardt N; Lead Discovery Wuppertal, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Beck-Sickinger AG; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany.
Bierer D; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.

ChemMedChem ; 11(21): 2378-2384, 2016 Nov 07.

Article en En | MEDLINE | ID: mdl-27558296

Palabras clave

Gâprotein-coupled receptors; apelin; lipidation; peptides; structure-activity relationships

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Alemania

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