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Arterial Stiffness Impairment in Sickle Cell Disease Associated With Chronic Vascular Complications: The Multinational African CADRE Study.
Ranque, Brigitte; Menet, Aymeric; Boutouyrie, Pierre; Diop, Ibrahima Bara; Kingue, Samuel; Diarra, Mamadou; N'Guetta, Roland; Diallo, Dapa; Diop, Saliou; Diagne, Ibrahima; Sanogo, Ibrahima; Tolo, Aissata; Chelo, David; Wamba, Guillaume; Gonzalez, Jean Paul; Abough'elie, Cochise; Diakite, Cheick Oumar; Traore, Youssouf; Legueun, Gaëlle; Deme-Ly, Indou; Faye, Blaise Felix; Seck, Moussa; Kouakou, Boidy; Kamara, Ismael; Le Jeune, Sylvain; Jouven, Xavier.
Afiliación
  • Ranque B; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Menet A; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Boutouyrie P; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diop IB; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Kingue S; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diarra M; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • N'Guetta R; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diallo D; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diop S; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diagne I; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Sanogo I; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Tolo A; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Chelo D; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Wamba G; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Gonzalez JP; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Abough'elie C; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Diakite CO; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Traore Y; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Legueun G; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Deme-Ly I; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Faye BF; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Seck M; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Kouakou B; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Kamara I; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Le Jeune S; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
  • Jouven X; From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux d
Circulation ; 134(13): 923-33, 2016 09 27.
Article en En | MEDLINE | ID: mdl-27582423
ABSTRACT

BACKGROUND:

Although a blood genetic disease, sickle cell disease (SCD) leads to a chronic vasculopathy with multiple organ involvement. We assessed arterial stiffness in SCD patients and looked for associations between arterial stiffness and SCD-related vascular complications.

METHODS:

The CADRE (Coeur Artères et Drepanocytose, ie, Heart Arteries and Sickle Cell Disease) study prospectively recruited pediatric and adult SCD patients and healthy controls in Cameroon, Ivory Coast, Gabon, Mali, and Senegal. Patients underwent clinical examination, routine laboratory tests (complete blood count, serum creatinine level), urine albumin/creatinine ratio measure, and a measure of carotid-femoral pulse wave velocity (cf-PWV) and augmentation index (AI) at a steady state. The clinical and biological correlates of cf-PWV and AI were investigated by using a multivariable multilevel linear regression analysis with individuals nested in families further nested in countries.

RESULTS:

Included were 3627 patients with SCD and 943 controls. Mean cf-PWV was lower in SCD patients (7.5±2.0 m/s) than in controls (9.1±2.4 m/s, P<0.0001), and lower in SS-Sß(0) than in SC-Sß(+) phenotypes. AI, corrected for heart rate, increased more rapidly with age in SCD patients and was higher in SCD than in control adults. cf-PWV and AI were independently associated with age, sex, height, heart rate, mean blood pressure, hemoglobin level, country, and hemoglobin phenotype. After adjustment for these correlates, cf-PWV and AI were associated with the glomerular filtration rate and osteonecrosis. AI was also associated with stroke, pulmonary hypertension, and priapism, and cf-PWV was associated with microalbuminuria.

CONCLUSIONS:

PWV and AI are deeply modified in SCD patients in comparison with healthy controls. These changes are independently associated with a lower blood pressure and a higher heart rate but also with the hemoglobin phenotype. Moreover, PWV and AI are associated with several SCD clinical complications. Their prognostic value will be assessed at follow-up of the patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Presión Sanguínea / Rigidez Vascular / Frecuencia Cardíaca / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Circulation Año: 2016 Tipo del documento: Article
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Presión Sanguínea / Rigidez Vascular / Frecuencia Cardíaca / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Circulation Año: 2016 Tipo del documento: Article