Sox2: To crest or not to crest?

Mandalos, Nikolaos Panagiotis; Remboutsika, Eumorphia

Mandalos, Nikolaos Panagiotis; Remboutsika, Eumorphia.

Afiliación

Mandalos NP; National University of Athens Medical School, Department of Pediatrics, 75 Mikras Asias Str., 115 27, Athens, Greece; Stem Cell Biology Laboratory, Biomedical Sciences Research Centre "Alexander Fleming", 34 Fleming Str., 16672 Vari-Attica, Greece; Adjunct Faculty, The Lieber Institute for Brain Development, Basic Sciences Division, Johns Hopkins Medical Campus, 855 North Wolfe Str., Suite 300, 3rd Floor, Baltimore, MD 21205, USA.
Remboutsika E; National University of Athens Medical School, Department of Pediatrics, 75 Mikras Asias Str., 115 27, Athens, Greece; Stem Cell Biology Laboratory, Biomedical Sciences Research Centre "Alexander Fleming", 34 Fleming Str., 16672 Vari-Attica, Greece; Adjunct Faculty, The Lieber Institute for Brain Development, Basic Sciences Division, Johns Hopkins Medical Campus, 855 North Wolfe Str., Suite 300, 3rd Floor, Baltimore, MD 21205, USA. Electronic address: remboutsika@gmail.com.

Semin Cell Dev Biol ; 63: 43-49, 2017 03.

Article en En | MEDLINE | ID: mdl-27592260

ABSTRACT

ABSTRACT

Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominant role as a guardian of the developmental clock that ensures precision of cell flow in the developing head.

Asunto(s)

Cresta Neural/citología; Cresta Neural/metabolismo; Factores de Transcripción SOXB1/metabolismo; Animales; Humanos; Células-Madre Neurales/citología; Células-Madre Neurales/metabolismo

Palabras clave

Development; Differentiation; Embryonic stem cells; Induced pluripotent stem cells; Neural crest stem cells; Neural progenitor cells; Neural stem cells; Neurogenesis; Sox1; Sox14; Sox21; Sox3; SoxB1; SoxB2; Tissue regeneration

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción SOXB1 / Cresta Neural Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google