Caspase Inhibition Prevents Tumor Necrosis Factor-&#945;-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.

Ni, Hong-Min; McGill, Mitchell R; Chao, Xiaojuan; Woolbright, Benjamin L; Jaeschke, Hartmut; Ding, Wen-Xing

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.

Ni, Hong-Min; McGill, Mitchell R; Chao, Xiaojuan; Woolbright, Benjamin L; Jaeschke, Hartmut; Ding, Wen-Xing.

Afiliación

Ni HM; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
McGill MR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
Chao X; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
Woolbright BL; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
Ding WX; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas. Electronic address: wxding@kumc.edu.

Am J Pathol ; 186(10): 2623-36, 2016 10.

Article en En | MEDLINE | ID: mdl-27616656

Asunto(s)

Clorometilcetonas de Aminoácidos/farmacología; Apoptosis/efectos de los fármacos; Inhibidores de Caspasas/farmacología; Caspasas/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico; Factor de Necrosis Tumoral alfa/efectos adversos; Animales; Autofagia/efectos de los fármacos; Muerte Celular/efectos de los fármacos; Galactosamina/efectos adversos; Hepatocitos/efectos de los fármacos; Hepatocitos/fisiología; Lipopolisacáridos/efectos adversos; Hígado/metabolismo; Masculino; Ratones; Ratones Endogámicos BALB C; Modelos Biológicos; FN-kappa B/antagonistas & inhibidores; Necrosis/inducido químicamente

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Apoptosis / Caspasas / Enfermedad Hepática Inducida por Sustancias y Drogas / Inhibidores de Caspasas / Clorometilcetonas de Aminoácidos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Am J Pathol Año: 2016 Tipo del documento: Article

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