Discovery of N-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses.

Zhou, Zhong-Zhen; Cheng, Yu-Fang; Zou, Zheng-Qiang; Ge, Bing-Chen; Yu, Hui; Huang, Cang; Wang, Hai-Tao; Yang, Xue-Mei; Xu, Jiang-Ping

Zhou, Zhong-Zhen; Cheng, Yu-Fang; Zou, Zheng-Qiang; Ge, Bing-Chen; Yu, Hui; Huang, Cang; Wang, Hai-Tao; Yang, Xue-Mei; Xu, Jiang-Ping.

Afiliación

Zhou ZZ; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Cheng YF; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Zou ZQ; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Ge BC; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Yu H; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Huang C; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Wang HT; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.
Yang XM; Hygiene Detection Center, School of Public Health, Southern Medical University , Guangzhou 510515, China.
Xu JP; Department of Neuropharmacology and Novel Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, China.

ACS Chem Neurosci ; 8(1): 135-146, 2017 01 18.

Article en En | MEDLINE | ID: mdl-27690383

Asunto(s)

Antiinflamatorios/uso terapéutico; Antidepresivos/uso terapéutico; Depresión/tratamiento farmacológico; Encefalitis/tratamiento farmacológico; Inhibidores de Fosfodiesterasa 4/química; Inhibidores de Fosfodiesterasa 4/uso terapéutico; Animales; Antiinflamatorios/química; Antiinflamatorios/farmacocinética; Antidepresivos/química; Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4/metabolismo; Ciclooxigenasa 2/metabolismo; Modelos Animales de Enfermedad; Perros; Relación Dosis-Respuesta a Droga; Encefalitis/inducido químicamente; Conducta Exploratoria/efectos de los fármacos; Regulación de la Expresión Génica/efectos de los fármacos; Suspensión Trasera/métodos; Suspensión Trasera/psicología; Lipopolisacáridos/toxicidad; Masculino; Ratones; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular; Óxido Nítrico Sintasa de Tipo II/metabolismo; Rolipram/farmacología; Rolipram/uso terapéutico; Natación/psicología; Factor de Necrosis Tumoral alfa/metabolismo; Vómitos/tratamiento farmacológico; Vómitos/veterinaria

Palabras clave

N-Alkyl catecholamide; anti-neuroinflammation; antidepressant-like effects; less side-effect; selective phosphodiesterase-4 inhibitors; structure−activity relationships

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Depresión / Encefalitis / Inhibidores de Fosfodiesterasa 4 / Antiinflamatorios / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ACS Chem Neurosci Año: 2017 Tipo del documento: Article País de afiliación: China

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