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Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.
Chow, Edwin C Y; Quach, Holly P; Zhang, Yueping; Wang, Jason Z Y; Evans, David C; Li, Albert P; Silva, Jose; Tirona, Rommel G; Lai, Yurong; Pang, K Sandy.
Afiliación
  • Chow EC; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Quach HP; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Zhang Y; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Wang JZ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Evans DC; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Li AP; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Silva J; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Tirona RG; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Lai Y; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
  • Pang KS; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (E.C.Y.C., H.P.Q., J.Z.Y.W., K.S.P.); Bristol Myers Squibb, Pharmaceutical Candidate Optimization Department, Princeton, New Jersey (Y.Z., Y.L.); Pharmacokinetics, Dynamics, and Met
J Pharmacol Exp Ther ; 360(1): 174-191, 2017 Jan.
Article en En | MEDLINE | ID: mdl-27789682
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Transducción de Señal / Homeostasis / Intestinos / Hígado Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Transducción de Señal / Homeostasis / Intestinos / Hígado Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article