Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

Young, Patricia A; Migliorini, Mary; Strickland, Dudley K

Young, Patricia A; Migliorini, Mary; Strickland, Dudley K.

Afiliación

Young PA; From the Center for Vascular and Inflammatory Disease and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Migliorini M; From the Center for Vascular and Inflammatory Disease and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Strickland DK; From the Center for Vascular and Inflammatory Disease and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 dstrickland@som.umaryland.edu.

J Biol Chem ; 291(50): 26035-26044, 2016 Dec 09.

Article en En | MEDLINE | ID: mdl-27794518

Asunto(s)

Factor VIII/metabolismo; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/metabolismo; Complejos Multiproteicos/metabolismo; Animales; Sitios de Unión; Línea Celular; Cricetinae; Factor VIII/química; Factor VIII/genética; Humanos; Cinética; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/química; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/genética; Masculino; Complejos Multiproteicos/química; Complejos Multiproteicos/genética; Resonancia por Plasmón de Superficie

Palabras clave

LRP; blood coagulation; endocytosis; factor VIII (FVIII); ligand; lipoprotein receptor; lipoprotein receptor-related protein (LPR); lysine; surface plasmon resonance (SPR)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor VIII / Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Complejos Multiproteicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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