PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.

Chen, Yanbo; Deng, Jianwen; Wang, Peng; Yang, Mengxue; Chen, Xiaoping; Zhu, Li; Liu, Jianghong; Lu, Bingwei; Shen, Yan; Fushimi, Kazuo; Xu, Qi; Wu, Jane Y

Chen, Yanbo; Deng, Jianwen; Wang, Peng; Yang, Mengxue; Chen, Xiaoping; Zhu, Li; Liu, Jianghong; Lu, Bingwei; Shen, Yan; Fushimi, Kazuo; Xu, Qi; Wu, Jane Y.

Afiliación

Chen Y; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Deng J; Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 E. Superior, Chicago, IL, USA.
Wang P; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, China.
Yang M; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Chen X; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Zhu L; University of Chinese Academy of Sciences, Beijing, China.
Liu J; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Lu B; Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 E. Superior, Chicago, IL, USA.
Shen Y; Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 E. Superior, Chicago, IL, USA.
Fushimi K; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Xu Q; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Wu JY; Department of Pathology, Stanford University, School of Medicine, Stanford, CA, USA.

Hum Mol Genet ; 25(23): 5059-5068, 2016 12 01.

Article en En | MEDLINE | ID: mdl-27794540

Asunto(s)

Esclerosis Amiotrófica Lateral/genética; Proteínas de Drosophila/genética; Degeneración Lobar Frontotemporal/genética; Ribonucleoproteína Heterogénea-Nuclear Grupo F-H/genética; Degeneración Nerviosa/genética; Proteínas Serina-Treonina Quinasas/genética; Ubiquitina-Proteína Ligasas/genética; Esclerosis Amiotrófica Lateral/patología; Animales; Animales Modificados Genéticamente; Transporte Axonal/genética; Modelos Animales de Enfermedad; Degeneración Lobar Frontotemporal/fisiopatología; Regulación de la Expresión Génica; Genes Modificadores/genética; Humanos; Mitocondrias/genética; Mitocondrias/metabolismo; Mitocondrias/patología; Neuronas Motoras/metabolismo; Neuronas Motoras/patología; Mutación Missense; Degeneración Nerviosa/patología; Fenotipo; Proteínas de Unión al GTP rho/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Proteínas de Drosophila / Ribonucleoproteína Heterogénea-Nuclear Grupo F-H / Ubiquitina-Proteína Ligasas / Degeneración Lobar Frontotemporal / Esclerosis Amiotrófica Lateral / Degeneración Nerviosa Límite: Animals / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: China

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