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Single ocular injection of a sustained-release anti-VEGF delivers 6months pharmacokinetics and efficacy in a primate laser CNV model.
Adamson, Peter; Wilde, Thomas; Dobrzynski, Eric; Sychterz, Caroline; Polsky, Rodd; Kurali, Edit; Haworth, Richard; Tang, Chi-Man; Korczynska, Justyna; Cook, Fiona; Papanicolaou, Irene; Tsikna, Lemy; Roberts, Chris; Hughes-Thomas, Zoe; Walford, James; Gibson, Daniel; Warrack, John; Smal, Jos; Verrijk, Ruud; Miller, Paul E; Nork, T Michael; Prusakiewicz, Jeffery; Streit, Timothy; Sorden, Steven; Struble, Craig; Christian, Brian; Catchpole, Ian R.
Afiliación
  • Adamson P; GSK Ophthalmology, Stevenage, UK; GSK, King of Prussia, PA, USA; ProQR Therapeutics NV, Zernikedreef 9, 2333CR Leiden, The Netherlands.
  • Wilde T; Drug Metabolism & Pharmacokinetics, UK; GSK, King of Prussia, PA, USA; Janssen Research & Development, PA 19002, USA.
  • Dobrzynski E; Drug Metabolism & Pharmacokinetics, UK; GSK, King of Prussia, PA, USA.
  • Sychterz C; Drug Metabolism & Pharmacokinetics, UK; GSK, King of Prussia, PA, USA.
  • Polsky R; Safety Assessment, King of Prussia, PA, USA; GSK, King of Prussia, PA, USA.
  • Kurali E; Target Science Statistics, Leiden, The Netherlands; Janssen Research & Development, PA 19002, USA.
  • Haworth R; Safety Assessment, King of Prussia, PA, USA; GSK Ware, UK.
  • Tang CM; BioPharm Innovation, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK; MedImmune, Granta Park, Cambridge, UK.
  • Korczynska J; BioPharm Discovery, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK.
  • Cook F; BioPharm Discovery, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK.
  • Papanicolaou I; BioPharm Innovation, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK.
  • Tsikna L; BioPharm Discovery, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK; Avacta Life Sciences, Whittlesford, Cambridge, UK.
  • Roberts C; BioPharm Discovery, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK.
  • Hughes-Thomas Z; BioPharm Discovery, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK.
  • Walford J; BioPharm Process Research, Zernikedreef 9, 2333CR Leiden, The Netherlands; GSK Medicines Research Centre, Stevenage, UK.
  • Gibson D; BioPharm Process Research, Zernikedreef 9, 2333CR Leiden, The Netherlands; GSK Medicines Research Centre, Stevenage, UK.
  • Warrack J; AnalyticalSciences, Granta Park, Cambridge, UK; GSK Medicines Research Centre, Stevenage, UK.
  • Smal J; OctoPlus NV, Leiden, The Netherlands.
  • Verrijk R; OctoPlus NV, Leiden, The Netherlands.
  • Miller PE; OSOD, Madison, WI, USA.
  • Nork TM; OSOD, Madison, WI, USA; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Prusakiewicz J; Covance, Madison, WI, USA.
  • Streit T; Covance, Madison, WI, USA.
  • Sorden S; Covance, Madison, WI, USA.
  • Struble C; Covance, Madison, WI, USA.
  • Christian B; Covance, Madison, WI, USA.
  • Catchpole IR; GSK Ophthalmology, Stevenage, UK; BioPharm Innovation, Madison, WI, USA; GSK Medicines Research Centre, Stevenage, UK. Electronic address: ian.r.catchpole@gsk.com.
J Control Release ; 244(Pt A): 1-13, 2016 12 28.
Article en En | MEDLINE | ID: mdl-27810558
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos Fc de Inmunoglobulinas / Neovascularización Coroidal / Factor A de Crecimiento Endotelial Vascular / Anticuerpos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos Fc de Inmunoglobulinas / Neovascularización Coroidal / Factor A de Crecimiento Endotelial Vascular / Anticuerpos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos