miR-429 is involved in regulation of NF-κBactivity by targeting IKKß and suppresses oncogenic activity in cervical cancer cells.

ABSTRACT

Dysregulation of microRNAs (miRNAs) can contribute to tumorigenesis in cancers. In this study, we found that miR-429 was downregulated in cervical cancer (CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKKß was a novel target gene of miR-429 and ectopic expression of IKKß abrogated the phenotypes induced by miR-429. When IKKß was downregulated by miR-429, nuclear factor κB (NF-κB) pathway activation, interleukin-6 (IL-6), and interferon-ß (IFN-ß) production were decreased in CC cells. These findings indicate that miR-429 is involved in regulation of the NF-κB pathway by targeting IKKß and functions as a tumor suppressor in cervical carcinogenesis.