Regulation of Contractile Responses of Vascular Smooth Muscle Cells under Conditions of Hypoxia-Reoxygenation.
Bull Exp Biol Med
; 162(2): 195-198, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-27913935
ABSTRACT
We analyzed the effects of hypoxia and reoxygenation on changes in contractile activity in rat aortic smooth muscles. Both hypoxia and reoxygenation induced relaxation of smooth muscle cells precontracted with high-potassium Krebs solution (30 mM KCl) or α1-adrenoceptor agonist phenylephrine. Vasodilation resulted from enhancement of potassium permeability of smooth muscle cell membranes caused by activation of voltage-gated potassium channels (triggered by both precontracting agents) or by opening of ATP-sensitive potassium channels (phenylephrine). In isolated smooth muscle cells, both hypoxia and inhibition of Na+,K+-ATPase with ouabain led to depletion of intracellular store of macroergic substances, reduced potassium concentration, and elevated the content of sodium ions.
Palabras clave
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Potasio
/
Sodio
/
Contracción Isométrica
/
Hipoxia
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2016
Tipo del documento:
Article
País de afiliación:
Rusia