Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury.

Usui, Toru; Whitaker, Paul; Meng, Xiaoli; Watson, John; Antoine, Daniel J; French, Neil S; Park, B Kevin; Naisbitt, Dean J

Usui, Toru; Whitaker, Paul; Meng, Xiaoli; Watson, John; Antoine, Daniel J; French, Neil S; Park, B Kevin; Naisbitt, Dean J.

Afiliación

Usui T; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Whitaker P; Department of Respiratory Medicine, St James's Hospital , Beckett Street, Leeds LS9 7TF, England.
Meng X; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Watson J; Department of Respiratory Medicine, St James's Hospital , Beckett Street, Leeds LS9 7TF, England.
Antoine DJ; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
French NS; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Park BK; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Naisbitt DJ; Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

Chem Res Toxicol ; 29(11): 1793-1795, 2016 11 21.

Article en En | MEDLINE | ID: mdl-27933861

ABSTRACT

ABSTRACT

Antituberculosis (TB) drug exposure is associated with a mild elevation of liver enzymes that occasionally develops into severe liver injury. Herein, we identify ethambutol- and rifampicin-specific CD4+ and CD8+ T-cell clones in a patient with fatal anti TB-related liver injury. The clones were activated to proliferate and secrete IFN-Î³, Il-13, and granzyme B following drug treatment. Drug-responsive T-cells may contribute to the pathogenesis of antituberculosis-related liver failure.

Asunto(s)

Antituberculosos/efectos adversos; Enfermedad Hepática Inducida por Sustancias y Drogas/etiología; Linfocitos T/efectos de los fármacos; Tuberculosis Pulmonar/tratamiento farmacológico; Resultado Fatal; Humanos; Masculino; Persona de Mediana Edad; Linfocitos T/inmunología; Tuberculosis Pulmonar/inmunología

Buscar en Google

Imprimir

XML

PubMed Links

Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Linfocitos T / Enfermedad Hepática Inducida por Sustancias y Drogas / Antituberculosos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

Buscar en Google

Imprimir

XML

PubMed Links