Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones.

Kumarasamy, Dhanabal; Roy, Biswajit Gopal; Rocha-Pereira, Joana; Neyts, Johan; Nanjappan, Satheeshkumar; Maity, Subhasis; Mookerjee, Musfiqua; Naesens, Lieve

Kumarasamy, Dhanabal; Roy, Biswajit Gopal; Rocha-Pereira, Joana; Neyts, Johan; Nanjappan, Satheeshkumar; Maity, Subhasis; Mookerjee, Musfiqua; Naesens, Lieve.

Afiliación

Kumarasamy D; Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, 124, B.L Saha Road, Kolkata 700053, India. Electronic address: dhanabalrx@gmail.com.
Roy BG; Department of Chemistry, School of Physical Sciences, Sikkim University, 6th Mile, Tadong, Gangtok, Sikkim 737102, India.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven 3000, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven 3000, Belgium.
Nanjappan S; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research [NIPER-H], Balanagar, Hyderabad 500037, India.
Maity S; Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, 124, B.L Saha Road, Kolkata 700053, India.
Mookerjee M; Department of Pharmaceutical Chemistry, NSHM College of Pharmaceutical Technology, 124, B.L Saha Road, Kolkata 700053, India.
Naesens L; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven 3000, Belgium.

Bioorg Med Chem Lett ; 27(2): 139-142, 2017 01 15.

Article en En | MEDLINE | ID: mdl-27979594

Asunto(s)

Antivirales/farmacología; Virus ADN/efectos de los fármacos; Pirimidinonas/farmacología; Virus ARN/efectos de los fármacos; Animales; Antivirales/síntesis química; Antivirales/toxicidad; Bunyaviridae/efectos de los fármacos; Gatos; Chlorocebus aethiops; Sulfato de Dextran/farmacología; Perros; Células HeLa; Humanos; Ácido Micofenólico/farmacología; Pirimidinonas/síntesis química; Pirimidinonas/toxicidad; Ribavirina/farmacología; Células Vero

Palabras clave

Antiviral activity; Bunyavirus; Cytotoxicity; DHPM; Dihydropyrimidinones

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Pirimidinonas / Virus ARN / Virus ADN Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article

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