Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Science
; 246(4927): 249-51, 1989 Oct 13.
Article
en En
| MEDLINE
| ID: mdl-2799385
ABSTRACT
Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interleucina-1
/
Interleucina-2
/
Proteínas Proto-Oncogénicas c-jun
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1989
Tipo del documento:
Article