Intracellular Nucleic Acid Detection in Autoimmunity.
Annu Rev Immunol
; 35: 313-336, 2017 04 26.
Article
en En
| MEDLINE
| ID: mdl-28142323
ABSTRACT
Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic acids. The existence of these sensors raises fundamental questions about self/nonself discrimination because of the abundance of self-DNA and self-RNA that occupy these same compartments. Recent advances have revealed that enzymes that metabolize or modify endogenous nucleic acids are essential for preventing inappropriate activation of the innate antiviral response. In this review, we discuss rare human diseases caused by dysregulated nucleic acid sensing, focusing primarily on intracellular sensors of nucleic acids. We summarize lessons learned from these disorders, we rationalize the existence of these diseases in the context of evolution, and we propose that this framework may also apply to a number of more common autoimmune diseases for which the underlying genetics and mechanisms are not yet fully understood.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virosis
/
Ácidos Nucleicos
/
Autoinmunidad
/
Enfermedades Autoinmunes del Sistema Nervioso
/
Lupus Eritematoso Sistémico
/
Malformaciones del Sistema Nervioso
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2017
Tipo del documento:
Article