Chloroquine attenuates TLR3/IFN-ß signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis.

Imaizumi, Tadaatsu; Hayakari, Ryo; Matsumiya, Tomoh; Yoshida, Hidemi; Tsuruga, Kazushi; Watanabe, Shojiro; Kawaguchi, Shogo; Tanaka, Hiroshi

Imaizumi, Tadaatsu; Hayakari, Ryo; Matsumiya, Tomoh; Yoshida, Hidemi; Tsuruga, Kazushi; Watanabe, Shojiro; Kawaguchi, Shogo; Tanaka, Hiroshi.

Afiliación

Imaizumi T; a Departments of Vascular Biology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
Hayakari R; a Departments of Vascular Biology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
Matsumiya T; a Departments of Vascular Biology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
Yoshida H; a Departments of Vascular Biology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
Tsuruga K; b Department of Pediatrics , Hirosaki University Hospital , Hirosaki , Japan.
Watanabe S; b Department of Pediatrics , Hirosaki University Hospital , Hirosaki , Japan.
Kawaguchi S; c Department of Gastroenterology and Hematology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
Tanaka H; a Departments of Vascular Biology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.

Mod Rheumatol ; 27(6): 1004-1009, 2017 Nov.

Article en En | MEDLINE | ID: mdl-28150518

Asunto(s)

Antirreumáticos/farmacología; Cloroquina/farmacología; Interferón beta/metabolismo; Nefritis Lúpica/metabolismo; Células Mesangiales/metabolismo; Transducción de Señal; Receptor Toll-Like 3/metabolismo; Células Cultivadas; Humanos; Interferón beta/genética; Células Mesangiales/efectos de los fármacos; FN-kappa B/genética; FN-kappa B/metabolismo; Factor de Transcripción STAT1/genética; Factor de Transcripción STAT1/metabolismo; Receptor Toll-Like 3/genética

Palabras clave

Chloroquine; NF-κB; TLR3; lupus nephritis; mesangial cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nefritis Lúpica / Transducción de Señal / Cloroquina / Interferón beta / Antirreumáticos / Células Mesangiales / Receptor Toll-Like 3 Límite: Humans Idioma: En Revista: Mod Rheumatol Año: 2017 Tipo del documento: Article País de afiliación: Japón

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