Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors.

Ge, Ying; Li, Aibo; Wu, Jianwei; Feng, Haiwei; Wang, Letian; Liu, Hongwu; Xu, Yungen; Xu, Qingxiang; Zhao, Li; Li, Yuyan

Ge, Ying; Li, Aibo; Wu, Jianwei; Feng, Haiwei; Wang, Letian; Liu, Hongwu; Xu, Yungen; Xu, Qingxiang; Zhao, Li; Li, Yuyan.

Afiliación

Ge Y; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Li A; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Wu J; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Feng H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Wang L; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Liu H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Xu Y; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Xu Q; Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, Nanjing 210008, China. Electronic address: xqx008dg@sina.com.
Zhao L; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhaolicpu@126.com.
Li Y; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yuyanli@cpu.edu.cn.

Eur J Med Chem ; 128: 180-191, 2017 Mar 10.

Article en En | MEDLINE | ID: mdl-28182990

Asunto(s)

Antineoplásicos/farmacología; Ácidos Borónicos/química; Proliferación Celular/efectos de los fármacos; Dipéptidos/farmacología; Diseño de Fármacos; Naftoquinonas/farmacología; Complejo de la Endopetidasa Proteasomal/química; Inhibidores de Proteasoma/farmacología; Animales; Antineoplásicos/química; Western Blotting; Bortezomib/farmacología; Células Cultivadas; Dipéptidos/química; Humanos; Masculino; Microsomas Hepáticos/efectos de los fármacos; Microsomas Hepáticos/metabolismo; Modelos Moleculares; Simulación del Acoplamiento Molecular; Estructura Molecular; Naftoquinonas/química; Inhibidores de Proteasoma/química; Ratas; Ratas Sprague-Dawley; Relación Estructura-Actividad

Palabras clave

1, 4-naphthoquinones; Docking studies; Non-peptide boronic acid; Proteasome inhibitors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos Borónicos / Diseño de Fármacos / Naftoquinonas / Complejo de la Endopetidasa Proteasomal / Proliferación Celular / Dipéptidos / Inhibidores de Proteasoma / Antineoplásicos Tipo de estudio: Evaluation_studies Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article País de afiliación: China

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