Synthesis of 1ß-hydroxydeoxycholic acid in H-2 and unlabeled forms.
J Labelled Comp Radiopharm
; 60(4): 221-229, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28183147
ABSTRACT
1ß-hydroxydeoxycholic acid in unlabeled and stable isotope labeled forms was required for use as a biomarker for Cytochrome P450 3A4/5 activity. A lengthy synthesis was undertaken to deliver the unlabeled compound and in the process, to develop a route to the deuterium labeled compound. The synthesis of the unlabeled compound was completed but in a very low yield. Concurrent with the synthetic approach, a biosynthetic route was pursued and this approach proved to be much more rapid and afforded the compound in both unlabeled and deuterium labeled forms in a 1-step oxidation from deoxycholic acid and [D4 ]deoxycholic acid, respectively.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Quenodesoxicólico
/
Deuterio
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Año:
2017
Tipo del documento:
Article
País de afiliación:
Suecia