How to handle adsorption of cerebrospinal fluid amyloid ß (1-42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aß<sub>42</sub>/Aß<sub>40</sub> ratio.

Willemse, Eline; van Uffelen, Kees; Brix, Britta; Engelborghs, Sebastiaan; Vanderstichele, Hugo; Teunissen, Charlotte

How to handle adsorption of cerebrospinal fluid amyloid ß (1-42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aß₄₂/Aß₄₀ ratio.

Willemse, Eline; van Uffelen, Kees; Brix, Britta; Engelborghs, Sebastiaan; Vanderstichele, Hugo; Teunissen, Charlotte.

Afiliación

Willemse E; Neurochemistry Laboratory, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology, Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address
van Uffelen K; Neurochemistry Laboratory, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Brix B; Neurodegenerative Diseases Department, EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Engelborghs S; Department of Biomedical Sciences, Reference Centre for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerpen, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerpen, Belgium.
Vanderstichele H; ADx NeuroSciences, Gent, Belgium.
Teunissen C; Neurochemistry Laboratory, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

Alzheimers Dement ; 13(8): 885-892, 2017 Aug.

Article en En | MEDLINE | ID: mdl-28222302

Asunto(s)

Péptidos beta-Amiloides/líquido cefalorraquídeo; Fragmentos de Péptidos/líquido cefalorraquídeo; Adsorción; Péptidos beta-Amiloides/química; Biomarcadores/líquido cefalorraquídeo; Ensayo de Inmunoadsorción Enzimática; Humanos; Modelos Lineales; Fragmentos de Péptidos/química; Fase Preanalítica/instrumentación; Encuestas y Cuestionarios; Factores de Tiempo

Palabras clave

Adsorption; Alzheimer's disease; Amyloid ß (140); Amyloid ß (142); Biobanking; Biomarkers; Cerebrospinal fluid; Preanalytical variation; Ratio Aß(42)/Aß(40)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2017 Tipo del documento: Article

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