Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.

Toczek, Jakub; Ye, Yunpeng; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Jung, Jae-Joon; Sadeghi, Mehran M

Toczek, Jakub; Ye, Yunpeng; Gona, Kiran; Kim, Hye-Yeong; Han, Jinah; Razavian, Mahmoud; Golestani, Reza; Zhang, Jiasheng; Wu, Terence L; Jung, Jae-Joon; Sadeghi, Mehran M.

Afiliación

Toczek J; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
Ye Y; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; and.
Gona K; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
Kim HY; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; and.
Han J; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
Razavian M; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; and.
Golestani R; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
Zhang J; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; and.
Wu TL; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
Jung JJ; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; and.
Sadeghi MM; Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.

J Nucl Med ; 58(8): 1318-1323, 2017 08.

Article en En | MEDLINE | ID: mdl-28360209

Asunto(s)

Aneurisma/diagnóstico por imagen; Aneurisma/metabolismo; Ácidos Hidroxámicos/metabolismo; Compuestos Macrocíclicos/metabolismo; Inhibidores de la Metaloproteinasa de la Matriz/metabolismo; Metaloproteinasas de la Matriz/metabolismo; Imagen Molecular/métodos; Niacina/análogos & derivados; Animales; Arterias Carótidas/diagnóstico por imagen; Diseño de Fármacos; Estabilidad de Medicamentos; Regulación Enzimológica de la Expresión Génica; Ácidos Hidroxámicos/química; Ácidos Hidroxámicos/farmacocinética; Compuestos Macrocíclicos/química; Compuestos Macrocíclicos/farmacocinética; Inhibidores de la Metaloproteinasa de la Matriz/química; Inhibidores de la Metaloproteinasa de la Matriz/farmacocinética; Ratones; Niacina/química; Niacina/metabolismo; Niacina/farmacocinética; Trazadores Radiactivos; Radioquímica; Distribución Tisular

Palabras clave

SPECT/CT; abdominal aortic aneurysm; inflammation; matrix metalloproteinase inhibitor; molecular imaging

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metaloproteinasas de la Matriz / Compuestos Macrocíclicos / Imagen Molecular / Inhibidores de la Metaloproteinasa de la Matriz / Ácidos Hidroxámicos / Aneurisma / Niacina Límite: Animals Idioma: En Revista: J Nucl Med Año: 2017 Tipo del documento: Article

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