Effects of K-877, a novel selective PPAR&#945; modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice.

Takei, Kenta; Nakagawa, Yoshimi; Wang, Yunong; Han, Song-Iee; Satoh, Aoi; Sekiya, Motohiro; Matsuzaka, Takashi; Shimano, Hitoshi

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice.

Takei, Kenta; Nakagawa, Yoshimi; Wang, Yunong; Han, Song-Iee; Satoh, Aoi; Sekiya, Motohiro; Matsuzaka, Takashi; Shimano, Hitoshi.

Afiliación

Takei K; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Nakagawa Y; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Wang Y; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Han SI; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Satoh A; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Sekiya M; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Matsuzaka T; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Shimano H; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan;

J Pharmacol Sci ; 133(4): 214-222, 2017 Apr.

Article en En | MEDLINE | ID: mdl-28366492

Asunto(s)

Aterosclerosis/tratamiento farmacológico; Aterosclerosis/genética; Benzoxazoles/farmacología; Benzoxazoles/uso terapéutico; Butiratos/farmacología; Butiratos/uso terapéutico; Expresión Génica/efectos de los fármacos; Hiperlipidemias/tratamiento farmacológico; Hiperlipidemias/genética; Intestino Delgado/metabolismo; Metabolismo de los Lípidos/efectos de los fármacos; PPAR alfa/agonistas; PPAR alfa/genética; Receptores de LDL/genética; Animales; Aterosclerosis/metabolismo; Colesterol/metabolismo; Modelos Animales de Enfermedad; Ácidos Grasos/metabolismo; Técnicas de Inactivación de Genes; Hiperlipidemias/metabolismo; Absorción Intestinal/efectos de los fármacos; Hígado/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Terapia Molecular Dirigida; Oxidación-Reducción/efectos de los fármacos

Palabras clave

Cholesterol absorption; HDL cholesterol; PPARα; SPPARMα

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzoxazoles / Butiratos / Receptores de LDL / Expresión Génica / PPAR alfa / Aterosclerosis / Metabolismo de los Lípidos / Hiperlipidemias / Intestino Delgado Límite: Animals Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón

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