Vascular impairment as a pathological mechanism underlying long-lasting cognitive dysfunction after pediatric traumatic brain injury.
Neurochem Int
; 111: 93-102, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28377126
ABSTRACT
Traumatic brain injury (TBI) is the leading cause of death and disability in children. Indeed, the acute mechanical injury often evolves to a chronic brain disorder with long-term cognitive, emotional and social dysfunction even in the case of mild TBI. Contrary to the commonly held idea that children show better recovery from injuries than adults, pediatric TBI patients actually have worse outcome than adults for the same injury severity. Acute trauma to the young brain likely interferes with the fine-tuned developmental processes and may give rise to long-lasting consequences on brain's function. This review will focus on cerebrovascular dysfunction as an important early event that may lead to long-term phenotypic changes in the brain after pediatric TBI. These, in turn may be associated with accelerated brain aging and cognitive dysfunction. Finally, since no effective treatments are currently available, understanding the unique pathophysiological mechanisms of pediatric TBI is crucial for the development of new therapeutic options.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Lesiones del Sistema Vascular
/
Disfunción Cognitiva
/
Lesiones Traumáticas del Encéfalo
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Child
/
Humans
Idioma:
En
Revista:
Neurochem Int
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia