Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model.
Pharm Biol
; 55(1): 1561-1568, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28385108
ABSTRACT
CONTEXT To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use. OBJECTIVE:
In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract. MATERIALS ANDMETHODS:
Adult male Wistar rats were divided into four groups Group I negative control; group II Ovalbumin sensitized/challenged rats (positive control); group III received UD extract (1.5 g/kg/day) orally along the experimental protocol; group IV received UD extract (1.5 g/kg/day) orally along the experimental protocol and sensitized/challenged with ovalbumin. After 25 days, blood and tissue samples were collected for haematological and histopathological analysis, respectively. The oxidative stress parameters were evaluated in the lungs, liver and erythrocytes. Then, correlations between markers of airway inflammation and markers of oxidative stress were explored.RESULTS:
UD extract significantly (p < 0.01) inhibited eosinophilia increases in BALF (-60%) and the levels of leucocytes (-32.75%) and lymphocytes (-29.22%) in serum, and effectively suppressed inflammatory cells recruitment in the asthmatic rat model. Besides, the lipid peroxidation generated by allergen administration was significantly (p < 0.05) diminished by UD treatment in lung tissue (-48.58%). The nettle extract was also investigated for the total phenolic content (30.79 ± 0.96 mg gallic acid/g dry extract) and shows DPPH radical scavenging activity with 152.34 ± 0.37 µg/mL IC50 value.CONCLUSIONS:
The results confirmed that UD administration might be responsible for the protective effects of this extract against airway inflammation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumonía
/
Asma
/
Extractos Vegetales
/
Peroxidación de Lípido
/
Ovalbúmina
/
Estrés Oxidativo
/
Antiasmáticos
/
Urtica dioica
/
Pulmón
/
Antiinflamatorios
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
Pharm Biol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Argelia