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Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients With BRCA 1/2-Mutated Cancer or PARP-Sensitive Tumor Types.
Niu, Jing; Scheuerell, Christie; Mehrotra, Shailly; Karan, Sharon; Puhalla, Shannon; Kiesel, Brian F; Ji, Jiuping; Chu, Edward; Gopalakrishnan, Mathangi; Ivaturi, Vijay; Gobburu, Jogarao; Beumer, Jan H.
Afiliación
  • Niu J; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Scheuerell C; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Mehrotra S; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Karan S; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Puhalla S; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Kiesel BF; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Ji J; Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Chu E; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Gopalakrishnan M; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Ivaturi V; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Gobburu J; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
  • Beumer JH; Center for Translational Medicine, School of Pharmacy, University of Maryland, Baltimore, MD, USA.
J Clin Pharmacol ; 57(8): 977-987, 2017 08.
Article en En | MEDLINE | ID: mdl-28387939
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencimidazoles / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Modelos Biológicos Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencimidazoles / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Modelos Biológicos Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos