Sponging off nature for new drug leads.
Biochem Pharmacol
; 139: 3-14, 2017 09 01.
Article
en En
| MEDLINE
| ID: mdl-28411115
ABSTRACT
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities that have been reported in the chemical literature since the early 1970s. During the last 40years, chemists in the Andersen laboratory at UBC, in collaboration with biologists, have discovered many novel bioactive sponge natural products. Four experimental drug candidates for treatment of inflammation and cancer, that were inspired by members of this sponge natural product collection, have progressed to phase I/II/III clinical trials. This review recounts the scientific stories behind the discovery and development of these four drug candidates; IPL576,092, HTI-286 (Taltobulin), EPI-506 (Ralaniten acetate), and AQX-1125.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Poríferos
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Productos Biológicos
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Diseño de Fármacos
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Drogas en Investigación
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Descubrimiento de Drogas
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Organismos Acuáticos
Idioma:
En
Revista:
Biochem Pharmacol
Año:
2017
Tipo del documento:
Article