Consecutive Sonogashira Coupling and Hydroamination Cyclization for the Synthesis of Isoindolo[1,2-b]quinazolin-10(12H)-ones Catalyzed by CuI/l-Proline.
J Org Chem
; 82(9): 4918-4923, 2017 05 05.
Article
en En
| MEDLINE
| ID: mdl-28421752
ABSTRACT
A consecutive Sonogashira coupling reaction, acetylene hydroamination cyclization of 2-(2-bromophenyl)quinazolin-4(3H)-ones and terminal alkynes, is described catalyzed by CuI/l-proline in the presence of Cs2CO3. This procedure provided a facile method for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-one derivatives in good yields.
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Colección:
01-internacional
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MEDLINE
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En
Revista:
J Org Chem
Año:
2017
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Article