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Congenital Zika Virus Infection Induces Severe Spinal Cord Injury.
Ramalho, Fernando S; Yamamoto, Aparecida Y; da Silva, Luis L; Figueiredo, Luiz T M; Rocha, Lenaldo B; Neder, Luciano; Teixeira, Sara R; Apolinário, Letícia A; Ramalho, Leandra N Z; Silva, Deisy M; Coutinho, Conrado M; Melli, Patrícia P; Augusto, Marlei J; Santoro, Ligia B; Duarte, Geraldo; Mussi-Pinhata, Marisa M.
Afiliación
  • Ramalho FS; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Yamamoto AY; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • da Silva LL; Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Figueiredo LTM; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Rocha LB; Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba.
  • Neder L; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Teixeira SR; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Apolinário LA; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Ramalho LNZ; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Silva DM; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Coutinho CM; Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Melli PP; Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Augusto MJ; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Santoro LB; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
  • Duarte G; Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Mussi-Pinhata MM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Clin Infect Dis ; 65(4): 687-690, 2017 08 15.
Article en En | MEDLINE | ID: mdl-28444144
ABSTRACT
We report 2 fatal cases of congenital Zika virus (ZIKV) infection. Brain anomalies, including atrophy of the cerebral cortex and brainstem, and cerebellar aplasia were observed. The spinal cord showed architectural distortion, severe neuronal loss, and microcalcifications. The ZIKV proteins and flavivirus-like particles were detected in cytoplasm of spinal neurons, and spinal cord samples were positive for ZIKV RNA.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Médula Espinal / Enfermedades de la Médula Espinal / Virus Zika / Infección por el Virus Zika Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article País de afiliación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Médula Espinal / Enfermedades de la Médula Espinal / Virus Zika / Infección por el Virus Zika Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2017 Tipo del documento: Article País de afiliación: Brasil