Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14&#945;-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.

Hargrove, Tatiana Y; Garvey, Edward P; Hoekstra, William J; Yates, Christopher M; Wawrzak, Zdzislaw; Rachakonda, Girish; Villalta, Fernando; Lepesheva, Galina I

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.

Hargrove, Tatiana Y; Garvey, Edward P; Hoekstra, William J; Yates, Christopher M; Wawrzak, Zdzislaw; Rachakonda, Girish; Villalta, Fernando; Lepesheva, Galina I.

Afiliación

Hargrove TY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Garvey EP; Viamet Pharmaceuticals, Durham, North Carolina, USA.
Hoekstra WJ; Viamet Pharmaceuticals, Durham, North Carolina, USA.
Yates CM; Viamet Pharmaceuticals, Durham, North Carolina, USA.
Wawrzak Z; Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois, USA.
Rachakonda G; Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, USA.
Villalta F; Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, USA.
Lepesheva GI; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA galina.i.lepesheva@vanderbilt.edu.

Antimicrob Agents Chemother ; 61(7)2017 07.

Article en En | MEDLINE | ID: mdl-28461309

Asunto(s)

Antifúngicos/farmacología; Aspergillus fumigatus/efectos de los fármacos; Aspergillus fumigatus/enzimología; Drogas en Investigación/farmacología; Esterol 14-Desmetilasa/metabolismo; Aspergillus fumigatus/genética; Candida albicans/efectos de los fármacos; Candida albicans/enzimología; Candida albicans/genética; Fluconazol/farmacología; Cetoconazol/farmacología; Pruebas de Sensibilidad Microbiana; Piridinas/farmacología; Esterol 14-Desmetilasa/genética; Tetrazoles/farmacología; Triazoles/farmacología; Voriconazol/farmacología

Palabras clave

Aspergillus fumigatus; VT-1598; X-ray structure; fungal infections; inhibition; sterol 14α-demethylase (CYP51)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Drogas en Investigación / Esterol 14-Desmetilasa / Antifúngicos Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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