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NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.
Rojas, Laura J; Hujer, Andrea M; Rudin, Susan D; Wright, Meredith S; Domitrovic, T Nicholas; Marshall, Steven H; Hujer, Kristine M; Richter, Sandra S; Cober, Eric; Perez, Federico; Adams, Mark D; van Duin, David; Bonomo, Robert A.
Afiliación
  • Rojas LJ; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Hujer AM; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Rudin SD; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Wright MS; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Domitrovic TN; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Marshall SH; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Hujer KM; J. Craig Venter Institute, La Jolla, California, USA.
  • Richter SS; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Cober E; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Perez F; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Adams MD; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • van Duin D; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Bonomo RA; Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Antimicrob Agents Chemother ; 61(7)2017 07.
Article en En | MEDLINE | ID: mdl-28461314
ABSTRACT
Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring blaNDM-5 and blaOXA-181 from a young man who underwent abdominal surgery in India. blaNDM-5 was located on an IncFII plasmid of ≈90 kb, whereas blaOXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a "hot-spot region" in the IncFII plasmid.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Beta-Lactamasas / Klebsiella pneumoniae Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Beta-Lactamasas / Klebsiella pneumoniae Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos