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Advances on the Transfer of Lipids by Lipid Transfer Proteins.
Wong, Louise H; Copic, Alenka; Levine, Tim P.
Afiliación
  • Wong LH; UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
  • Copic A; Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.
  • Levine TP; UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: tim.levine@ucl.ac.uk.
Trends Biochem Sci ; 42(7): 516-530, 2017 07.
Article en En | MEDLINE | ID: mdl-28579073
ABSTRACT
Transfer of lipid across the cytoplasm is an essential process for intracellular lipid traffic. Lipid transfer proteins (LTPs) are defined by highly controlled in vitro experiments. The functional relevance of these is supported by evidence for the same reactions inside cells. Major advances in the LTP field have come from structural bioinformatics identifying new LTPs, and from the development of countercurrent models for LTPs. However, the ultimate aim is to unite in vitro and in vivo data, and this is where much progress remains to be made. Even where in vitro and in vivo experiments align, rates of transfer tend not to match. Here we set out some of the advances that might test how LTPs work.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / Lípidos Límite: Humans Idioma: En Revista: Trends Biochem Sci Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Portadoras / Lípidos Límite: Humans Idioma: En Revista: Trends Biochem Sci Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido