Effects of chronic exposure to Formaldehyde on micronucleus rate of bone marrow cells in male mice.
J Pak Med Assoc
; 67(6): 933-935, 2017 Jun.
Article
en En
| MEDLINE
| ID: mdl-28585597
ABSTRACT
Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/ m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/ normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.
Palabras clave
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células de la Médula Ósea
/
Micronúcleos con Defecto Cromosómico
/
Desinfectantes
/
Formaldehído
Límite:
Animals
Idioma:
En
Revista:
J Pak Med Assoc
Año:
2017
Tipo del documento:
Article
País de afiliación:
China