Association of bullous pemphigoid with malignancy: A systematic review and meta-analysis.
J Am Acad Dermatol
; 77(4): 691-699, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28645646
ABSTRACT
BACKGROUND:
Studies evaluating whether malignancy rate is increased in patients with bullous pemphigoid (BP) have reached conflicting results.OBJECTIVE:
We sought to determine whether BP is associated with malignancy.METHOD:
Medline, EMBASE, the Cochrane library, and reference lists of included studies were searched for comparative studies that evaluated the relationship between BP and malignancy. Data were analyzed on the basis of studydesign:
cross-sectional, case control, and cohort. A meta-analysis was performed by using a random effects model to estimate pooled odds ratio.RESULTS:
The review included 8 studies. No association between BP and overall cancer was found for any of the study designs. Although a single cohort study reported an association with lymphoid leukemia and kidney and larynx cancer, a pooled analysis of case-control studies did not. A pooled analysis of cross-sectional studies found a significant association between BP and hematologic malignancies.LIMITATIONS:
The paucity of well-designed studies hindered the possibility of proving or disproving the BP-cancer association.CONCLUSION:
We did not find an association of BP with overall malignancy, but a possible association with hematologic malignancy was observed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Penfigoide Ampolloso
/
Neoplasias
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2017
Tipo del documento:
Article